Sulbactam Sodium/Cefoperazone Sodium combination is available as a dry powder for reconstitution in 1:1 in terms of free SBT/CPZ. Sulbactam Sodium is a derivative of the basic penicillin nucleus. It is an irreversible beta-lactamase inhibitor for parenteral use only.



Cefoperazone/Sulbactam is indicated for the treatment of the following infections when caused by susceptible organisms:

  • Respiratory tract infections (upper and lower)
  • Urinary tract infections (Upper and lower) 
  • Peritonitis, cholecystitis, cholangitis, and other Intra-abdominal infections
  • Septicemia
  • Meningitis
  • Skin and soft tissue infections
  • Bone and joint infections
  • Pelvic inflammatory disease, endometritis, gonorrhoea, and other infections of the genital tract 

Combination Therapy: 

Because of the broad-spectrum activity of cefoperazone/sulbactam, most infections can be treated adequately with this antibiotic alone. However, cefoperazonelsulbactam may be used concomitantly with other antibiotics if such combinations are indicated. If an aminoglycoside is used, renal function should be monitored during the course of therapy.


Daily dosage recommendations for sulbactam/cefoperazone in adults are as follows:



Sulbactam Activaity (g)

Cefoperazone Activity (g)


2.0 _ 4.0

1.0 _ 2.0

1.0 _ 2.0


Doses should be administered every 12 hours in equally divided doses. In severe or refractory infections, the daily dosage of cefoperazone/sulbactam may be increased up to 8g of the 1:1 ratio (i.e. 4g Cefoperazone activity), patients receiving the 1:1 ratio may require additional cefoperazone administered separately. Doses should be administered every 12 hours in equally divided doses. The recommended maximum daily dosage of sulbactam is 4g.


Cefoperazone/sulbactam is contraindicated in patients with known allergy to penicillin, sulbactam, cefoperazone, or any of the cephalosporins.


Xorbact is supplied in the following dosage forms, strengths and pack sizes: 

Xorbact 500mg IM/IV Injection: 

1 vial of 250mg Cefoperazone + 250mg Sulbactam and 1 ampoule of 5mLwater for injection. 

Xorbact 1g IM/IV Injection: 

1 vial of 500mg Cefoperazone + 500mg Sulbactam and 1 ampoule of 5mL water for injection. 

Xorbact 2g IM/IV Injection:

1 vial of 1g Cefoperazone + 1g Sulbactam and 1 ampoule of 10mL water for injection.

Patients should consult with their physician before taking any medicine.