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BRAND NAME:

Daploz 

GENERIC NAME:

Dapagliflozin

DESCRIPTION:

Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.

COMPOSITION:

Each film coated tablet contains: Daploz 5 mg tablet: Dapagliflozin (as dapagliflozin propanediol monohydrate) 5 mg. Daploz 10 mg tablet: Dapagliflozin (as dapagliflozin propanediol monohydrate) 10 mg. Daplozmet 5/850 mg tablet: Dapagliflozin (as dapagliflozin propanediol monohydrate) 5 mg. Metformin Hydrochloride B.P.850 mg. Daplozmet 5/1000 mg tablet: Dapagliflozin (as dapagliflozin propanediol monohydrate)5 mg. Metformin Hydrochloride B.P.1000 mg.

INDICATIONS:

Daploz/Daplozmet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes mellitus and established cardiovascular disease or multiple cardiovascular risk factors Daploz/Daplozmet is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.

DOSAGE & ADMINISTRATION:

To improve glycemic control in patients with T2D, the recommended starting dose of Daploz is 5 mg once daily, taken in the morning. In patients tolerating Daploz 5 mg once daily who require additional glycemic control, the dose can be increased to 10 mg once daily. To reduce the risk of hospitalization for heart failure in patients with T2D, the recommended dose of Daploz is 10 mg once daily

CONTRAINDICATIONS:

Prior serious hypersensitivity reaction to Daploz Severe renal impairment (eGFR <30 mL/min/1.73 m2), end-stage renal disease, or patients on dialysis

PRESENTATION:

Daploz 5 mg tablets: Alu. Alu. blister pack of 2 x 7’s. Daploz 10 mg tablets: Alu. Alu. blister pack of 2 x 7’s. Daplozmet 5/850 mg tablets: Alu. Alu. blister pack of 2 x 7’s. Daplozmet 5/1000 mg tablets: Alu. Alu. blister pack of 2 x 7’s.

Patients should consult with their physician before taking any medicine.

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